Arginine-rich, cell penetrating peptide–anti-microRNA complexes decrease glioblastoma migration potential
نویسندگان
چکیده
منابع مشابه
Arginine-rich, cell penetrating peptide-anti-microRNA complexes decrease glioblastoma migration potential.
MicroRNAs (miRNAs) are a class of gene regulators originating from non-coding endogenous RNAs. Altered expression, both up- and down-regulation, of miRNAs plays important roles in many human diseases. Correcting miRNA dysregulation by either inhibiting or restoring miRNA function may provide therapeutic benefit. However, efficient, nontoxic miRNA delivery systems are in need. Cell penetrating p...
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Arginine-rich cell-penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells. While successful intracellular delivery of many biologically active macromolecules has been accomplished using these peptides, their mechanisms of cell entry are still under investigation. Recent dialogue has centered on a debate over the roles that direct transloc...
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Most bioactive macromolecules, such as DNA and RNA, cannot permeate into cells freely from outside the plasma membrane. Cell penetrating peptides are a group of short peptide sequences that are able to transverse the cell membrane for mediating gene into living cells. In this study we demonstrate two cell penetrating peptides 5H-R9-C and 7H-R9-7H-C. These peptides are synthesized by solid phase...
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Small-angle X-ray scattering (SAXS) measurements reveal a striking difference in intermolecular interactions between two short highly charged peptides-deca-arginine (R10) and deca-lysine (K10). Comparison of SAXS curves at high and low salt concentration shows that R10 self-associates, while interactions between K10 chains are purely repulsive. The self-association of R10 is stronger at lower i...
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The transient gene delivery systems are generally mediated by viral infection, particle bombardment, electroporation, and microinjection for transferring exogenous DNAs into host cells. Recently, the peptide-mediated DNA delivery system became a novel tool for gene transfer, and these peptides, such as cell-penetrating peptides (CPPs), contained the ability of permeating plasma membranes and ca...
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ژورنال
عنوان ژورنال: Peptides
سال: 2014
ISSN: 0196-9781
DOI: 10.1016/j.peptides.2014.06.008